| Date/Time | Topics | Lecturer |
Mon 09 Jun 2014
09:00 - 12:00 |
L1: Molecular Level: Central Dogma & Replication
-Central dogma and nucleic acid structure
-DNA Replication
|
MF
|
Wed 11 Jun 2014
09:00 - 12:00 |
L2: Molecular Level: Transcription
• Transcription machinery
• Transcription regulation |
MF |
Fri 13 Jun 2013
09:00 - 12:00 |
L3: Molecular Level: Translation
• Translation machinery
• Stages in translation |
MF |
Mon 16 Jun 2014
09:00 - 12:00
|
L4: Molecular Level: Spontaneous and Induced Mutations as Drivers of Evolution
• Introduction into Core Curriculum and CGAB501: The MIT perspective
• Research paper topic: Inflammation and Cancer
• Example: Hepatitis B and Aflatoxin (which will be covered in more detail later)
|
JME |
| 13:00 - 16:00 | Review 1 | MF |
Wed 18 Jun 2014
09:00 - 12:00
|
L5: Molecular Level: Spontaneous and Induced Mutations as Drivers of Evolution
• Spontaneous and induced mutations
• Mutator phenotype and cancer |
JME
|
Fri 20 Jun 2014
09:00 - 12:00
|
L6: Molecular Level: MMR and Evolution
• Mismatch repair and fast forward evolution
• Drug resistance driven by fast evolution
• Paper analysis (Arkin; Loeb) |
JME |
Mon 23 Jun 2014
09:00 - 12:00 |
L7: Molecular Level: Cancer
• Six steps of malignant transformation
• How conventional anticancer drugs target molecular pathways
• Review of molecular pathways of growth and energy metabolism
• Recent advances showing that specific metabolic networks of cancer cells determine
susceptibility to anticancer agents |
JME |
| 13:00 - 16:00 | Review 2 | JME/MF/TA |
Wed 25 Jun 2014
09:00 - 12:00 |
L8: Molecular Level: Cancer
• Metabolic networks of cancer and other growing cells
• Paper analysis (Ditsworth, Dawson) |
JME |
Fri 27 Jun 2014
09:00 - 12:00
|
L9: Cell Level: Innate Immunity 1
• Activation of innate immune system accelerates cancer development
• Chemistry of inflammation |
JME |
Mon 30 Jun 2014
09:00 - 12:00 |
L10: Cell Level: Innate Immunity 2
• Activation of innate immune system accelerates cancer development
• Chemistry of inflammation |
JME |
Tue 1 Jul 2014
09:00 - 12:00 | Review 3 | JME |
Wed 2 Jul 2014
09:00 - 12:00 |
L11: Cell Level to Organ Level
• Aflatoxin carcinogenesis as a paradigm in which inflammation by an infectious agent (Hepatitis B)
accelerates cancer initiated by a chemical (Aflatoxin)
|
JME |
Fri 4 Jul 2014
09:00 - 12:00 |
L12: Synergy and sensitivity modulation in biological networks
|
JME |
Tue 15 Jul 2014
09:00 - 12:00 |
L13: How to Identify a Functional Biomarker: A Case Study Involving Aflatoxin B1 and HBV
|
SC |
Mon 21 Jul 2014
09:00 - 12:00 |
Exam I |
Staff |
Tue 22 Jul 2014
13:00 - 16:00 |
L14: Cells to Tissues
• Extracellular Matrix |
RS |
Wed 23 Jul 2014
09:00 - 12:00 |
L15: Cancer at the Clinical Level
• Hematology and Oncology |
UN |
Fri 25 Jul 2014
09:00 - 12:00 |
L16: Cancer at the Clinical Level |
UN |
Mon 28 Jul 2014
09:00 - 12:00 |
L17: Cancer at the Clinical Level |
UN |
Wed 30 Jul 2014
09:00 - 12:00 |
L18: Cancer at the Clinical Level |
UN |
Fri 01 Aug 2014
09:00 - 12:00 |
L19: Cancer at the Clinical Level |
UN |
Late Aug
09:00 - 12:00 |
Proposal Presentation I |
Staff |
Late Sep
09:00 - 12:00 |
Proposal Presentation II |
Staff |
Late Oct
13:00 - 16:00 |
Proposal Presentation III |
Staff |
Mon 18 Aug 2014
09:00 - 12:00 |
Exam II |
Staff |
