====== CGAB 501: Class Schedule ======
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<note><COUNTDOWN:09.06.2014|CGAB 501></note>
~~NOCACHE~~
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**JME**
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: John Essigmann
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**RS** 
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: Ram Sasisekharan
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**UN** 
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: Uma Narayanasami
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**MF** 
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: Mayuree Fuangthong
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^ Date/Time  ^ Topics ^ Lecturer ^		
| **Mon  09 Jun 2014** \\ 09:00 - 12:00 | \\ **L1: Molecular Level: Central Dogma & Replication** \\ -Central dogma and nucleic acid structure\\ -DNA Replication\\ | \\ MF \\ \\ \\ | 
| **Wed  11 Jun 2014** \\ 09:00 - 12:00 | \\ **L2: Molecular Level: Transcription**\\ • Transcription machinery\\ • Transcription regulation | \\ MF | 	
| **Fri 13 Jun 2013** \\ 09:00 - 12:00 | \\ **L3: Molecular Level: Translation**\\ • Translation machinery\\ • Stages in translation | \\ MF | 
| **Mon 16 Jun 2014** \\ 09:00 - 12:00\\ | \\ **L4: Molecular Level: Spontaneous and Induced Mutations as Drivers of Evolution**\\ • Introduction into Core Curriculum and CGAB501:  The MIT perspective\\ • Research paper topic: Inflammation and Cancer\\ • Example:  Hepatitis B and Aflatoxin (which will be covered in more detail later)\\ | \\ JME | 
| 13:00 - 16:00  | **Review 1** | MF  |  		
| **Wed 18 Jun 2014** \\ 09:00 - 12:00\\  \\ \\  | \\ **L5: Molecular Level: Spontaneous and Induced Mutations as Drivers of Evolution**\\ • Spontaneous and induced mutations\\ • Mutator phenotype and cancer | \\ JME\\ \\ \\ |
| **Fri 20 Jun 2014** \\ 09:00 - 12:00\\  | \\ **L6: Molecular Level: MMR and Evolution**\\ • Mismatch repair and fast forward evolution\\ • Drug resistance driven by fast evolution\\ • Paper analysis (Arkin; Loeb) | \\ JME | 
| **Mon 23 Jun 2014** \\ 09:00 - 12:00 | \\ **L7: Molecular Level: Cancer**\\ • Six steps of malignant transformation\\ • How conventional anticancer drugs target molecular pathways\\ • Review of molecular pathways of growth and energy metabolism\\ • Recent advances showing that specific metabolic networks of cancer cells determine\\ susceptibility to anticancer agents | \\ JME |
| 13:00 - 16:00  | **Review 2** | JME/MF/TA  |   		
| **Wed 25 Jun 2014** \\ 09:00 - 12:00 | \\ **L8: Molecular Level: Cancer**\\ • Metabolic networks of cancer and other growing cells\\ • Paper analysis (Ditsworth, Dawson) | \\ JME |
| **Fri 27 Jun 2014** \\ 09:00 - 12:00\\ | \\ **L9: Cell Level: Innate Immunity 1**\\ • Activation of innate immune system accelerates cancer development\\ • Chemistry of inflammation | \\ JME | 	
| **Mon 30 Jun 2014** \\ 09:00 - 12:00 | \\ **L10: Cell Level: Innate Immunity 2**\\ • Activation of innate immune system accelerates cancer development\\ • Chemistry of inflammation| \\ JME | 
| **Tue  1 Jul 2014**  \\ 09:00 - 12:00  | **Review 3** | JME  | 
| **Wed  2 Jul 2014**  \\ 09:00 - 12:00 | \\ **L11: Cell Level to Organ Level**\\ • Aflatoxin carcinogenesis as a paradigm in which inflammation by an infectious agent (Hepatitis B)\\ accelerates cancer initiated by a chemical (Aflatoxin)\\   | \\ JME | 
| **Fri  4 Jul 2014**  \\ 09:00 - 12:00 | \\ **L12: Synergy and sensitivity modulation in biological networks**\\   | \\ JME | 	
| **Tue  15 Jul 2014**  \\ 09:00 - 12:00 | \\ **L13: How to Identify a Functional Biomarker: A Case Study Involving Aflatoxin B1 and HBV**\\   | \\ SC | 
| **Mon 21 Jul 2014** \\ 09:00 - 12:00  | \\ **Exam I** | \\ Staff | 
| **Tue 22 Jul 2014** \\ 13:00 - 16:00 | \\ **L14: Cells to Tissues**\\ • Extracellular Matrix| \\ RS | 
| **Wed  23 Jul 2014** \\ 09:00 - 12:00 | \\ **L15: Cancer at the Clinical Level**\\ • Hematology and Oncology  | \\ UN | 	
| **Fri  25 Jul 2014** \\ 09:00 - 12:00 | \\ **L16: Cancer at the Clinical Level** | \\ UN | 
| **Mon 28 Jul 2014** \\ 09:00 - 12:00 | \\ **L17: Cancer at the Clinical Level** | \\ UN | 
| **Wed 30 Jul 2014** \\ 09:00 - 12:00 | \\ **L18: Cancer at the Clinical Level** | \\ UN | 	
| **Fri 01 Aug 2014** \\ 09:00 - 12:00 | \\ **L19: Cancer at the Clinical Level** | \\ UN | 
| **Late Aug**  \\ 09:00 - 12:00 | \\ **Proposal Presentation I** | \\ Staff | 
| **Late Sep**  \\ 09:00 - 12:00 | \\ **Proposal Presentation II** | \\ Staff | 
| **Late Oct**  \\ 13:00 - 16:00 | \\ **Proposal Presentation III** | \\ Staff | 	
| **Mon 18 Aug 2014** \\ 09:00 - 12:00    | \\ **Exam II** | \\ Staff |